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pentobarbital will reduce the level or result of conjugated estrogens by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.pentobarbital will decrease the level or outcome of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is really a sensitive CYP3A4 substrate. Coadm